TechCrunch Disrupt 2025 AI Stage: Full Agenda Revealed

The upcoming TechCrunch Disrupt 2025 has unveiled a comprehensive lineup for its dedicated AI Stage, bringing together industry pioneers to dissect the current trajectory of machine intelligence. From generative AI tools and developer infrastructure to the complexities of autonomous systems and national security, the program aims to provide founders with a roadmap for the next wave of innovation.
Key Themes and Industry Leaders
The event will feature direct insights from teams at Character.AI, Hugging Face, Mercor, Runway, and Wayve. Sessions are structured to move beyond surface-level discussion, focusing on the practical strategies and technical breakthroughs currently defining the field.
Investment and Strategic Outlook
A panel featuring Aileen Lee (Cowboy Ventures), Steve Jang (Kindred Ventures), and Jon McNeill (DVx Ventures) will analyze the investment landscape. The discussion will center on distinguishing genuine utility from market hype and identifying the most promising frontiers for new startups.
Autonomous Systems and Physical AI
The transition of AI from digital interfaces to the physical world will be a major focus:
- Driving Intelligence: Wayve CEO Alex Kendall will present on end-to-end autonomous driving systems trained on real-world data.
- Intelligence in Motion: Jeff Cardenas (Apptronik) and Raquel Urtasun (Waabi) will discuss the deployment of humanoid robots and autonomous trucking.
- Future of Transportation: Uber CTO Praveen Naga and Nuro co-founder Dave Ferguson will explore the evolution of mobility and delivery services.
Infrastructure and Development Tools
The technical backbone of AI remains a competitive arena. Thomas Wolf, co-founder and CSO of Hugging Face, will break down the battle over models and frameworks. Additionally, Kirill Skrygan, CEO of JetBrains, will address the practical reality of AI integration into daily developer workflows.
Conversational AI and Creative Machines
Karandeep Anand, CEO of Character.AI, will discuss the evolution of digital personalities and human-computer interaction. Parallel sessions on creative machines will feature insights from Twelve Labs, Wonder Dynamics (an Autodesk company), and PocketFM, alongside Runway’s chief design officer, Alejandro Matamala Ortiz, who will detail the rise of generative video in professional media.
National Security and Specialized Applications
The intersection of AI and national security will feature high-level perspectives from both the private and public sectors:
- Modern Defense: Mach Industries CEO Ethan Thornton will discuss startup contributions to defense technology.
- Strategic Innovation: A panel including DARPA director Kathleen Fisher, Point72 managing partner Sri Chandrasekar, and U.S. Navy CTO Justin Fanelli will examine the high-stakes acceleration of defense-related AI.
Social and Enterprise Integration
The program also covers the broader societal impact of algorithms. Dr. Amanda Gesselman (Kinsey Institute), Mark Kantor (Tinder), and Eugenia Kuyda (Replika) will explore AI’s influence on human relationships. On the enterprise side, Google Cloud CTO Will Grannis will share operational lessons for startups looking to scale their AI stacks effectively, while Mercor CEO Brendan Foody will address how automation is reshaping the future of work and hiring.